Sassafras Leaves Histamine Information

Sassafras leaves, primarily recognized for their role in traditional and medicinal cuisine, have no reported correlation with directly influencing histamine levels in the body, according to the research currently available in public databases (1). However, sassafras contains compounds including safrole and tannins (2), which may indirectly affect histamine activity. Safrole, once ingested, transforms into compounds that can disturb various bodily functions. Even though there's no concrete evidence linking it to histamine levels, the fact that it can alter biological activity necessitates a cautious approach to its consumption, preferably under dietary or healthcare supervision (3). Tannins, on the other hand, have demonstrated anti-inflammatory and antioxidant properties which could potentially contribute to reducing histamine release, thus indirectly influencing histamine levels. However, the strength and specificity of this correlation requires further investigation to be definitively confirmed (4). In conclusion, while no direct relationship has been established between eating sassafras leaves and alteration of histamine levels, the ingredients they contain (safrole and tannins) might have indirect implications on histamine activity. However, this product hasn't been researched well enough to publish concrete information regarding its relationship with histamine. As newer data surfaces, our team will work diligently to update this information. In the absence of substantial research, a diet that minimizes intake of histamine-rich foods as listed above is recommended for individuals sensitive to histamine. Anyone considering sassafras as a dietary supplement should seek professional advice due to the potential risks associated with safrole. References: 1. USDA Plants Database: https://plants.usda.gov/core/profile?symbol=SASS2 2. Duke, J. A. Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants. (1992) 3. National Toxicology Program Report on Carcinogens, Fourteenth Edition; U.S. Department of Health and Human Services: https://ntp.niehs.nih.gov/go/roc14 4. Okuda T., et al. (1998). Systematics and Health Effects of Chemically Distinct Tannins in Medicinal Plants. Phytochemistry - 48(4), 601-623.