Mace Spice Histamine Information

Mace spice, derived from the outer covering of the nutmeg seed, is commonly used in cooking for its flavor-enhancing properties. However, its direct impact on histamine levels is not well-documented in scientific literature, making it difficult to provide a definitive answer. Notwithstanding, one can draw conclusions based on the characteristics of its parent spice, nutmeg. Nutmeg is a known allergen and, since allergens typically provoke the release of histamines, one might assume that mace as a derivative, could generate a similar response. However, this is conjectural and lacks empirical substantiation. Even so, other components in mace such as myristicin and safrole, have been investigated. Myristicin, especially, is known to inhibit monoamine oxidase, an enzyme involved in the metabolization and inactivation of histamines and other monoamine compounds. Therefore, consumption of mace, by way of myristicin, could contribute to higher levels of histamine in the body. Yet, the quantity of myristicin in mace and its exact effect on histamine metabolism calls for further research. Additionally, individuals with a history of histamine intolerance might exhibit sensitivity towards spices, including mace, and experience histamine-related symptoms. This is due to spices' potential role as histamine liberators or in impeding the breakdown of histamines. Again, supportive data is specifically lacking for mace spice. Given the limited understanding around the specific connection between mace spice and histamine levels, it's essential to advise that individual tolerance and reactions can vary widely. In the event of known or suspected histamine intolerance, it's recommended to consult a healthcare professional before incorporating high histamine or potential histamine liberator foods into one's diet. References: 1. [Potential Allergens in Spices](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667286/) 2. [Monoamine Oxidase Inhibition by Myristicin](https://ayubmed.edu.pk/JAMC/PAST/21-4/Bashir.pdf) 3. [Histamine Intolerance: The Current State of the Art](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461759/) 4. [Histamine and Histamine Intolerance](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839887/) 5. [Safrole: a hepatocarcinogen that could be modulating histamine](https://www.sciencedirect.com/science/article/abs/pii/S1382668907001990) This product has not been researched well enough to publish any informations. Our team is still working to collate more data on the topic. More data will be available soon.