Pepperoni Pizza Histamine Information

Pepperoni pizza, a popular food item, can affect an individual's histamine level in several ways due to its varied ingredients each potentially impacting the histamine level differently. The primary components of a pepperoni pizza are the crust (usually made with yeast), tomato sauce, cheese, and pepperoni. Yeasted baked goods like the pizza crust are identified as food items rich in histamine. Moreover, tomatoes, used in the sauce, are known for having a high histamine content, while cheese, depending on its ripening process, can also introduce significant levels of histamine (1). This combination of high-histamine ingredients suggests that pepperoni pizza might elevate histamine levels for susceptible individuals (2). Pepperoni used on pizzas is a type of cured and spiced meat. Cured meats like pepperoni are potentially high in histamine, depending on the curing process and shelf life, so consuming such can contribute to increased histamine level (3). On the flip side, the mozzarella cheese often used on pizza has been suggested, per some sources, to possibly have histamine-lowering effects, given its relatively low histamine content compared to other cheeses. However, corroborated scientific research supporting this is currently lacking. As per the provided guidelines, caution is advised due to certain ingredients potentially acting as histamine liberators or substances that can delay the breakdown of histamine like yeast in the pizza crust (4). In conclusion, eating pepperoni pizza can result in a higher histamine level due to the presence of several histamine-rich ingredients and histamine liberators. Though there are some aspects related to cheese and its potential to lower histamine levels, more research is required to fully understand this relationship. References: 1. Maintz, L., & Novak, N. (2007); Histamine and histamine intolerance; The American Journal of Clinical Nutrition. 2. Enko, D., Kriegshauser, G., Stolba, R., Mangge, H., & Halwachs-Baumann, G. (2016); Serum diamine oxidase activity is associated with lactose malabsorption phenotypic variation; Clinical Biochemistry. 3. Amon, U., Bangha, E., Küster, T., Menne, A., Vollrath, I.B. and Gibbs, B.F. (1999); Enteral histaminosis: clinical implications; Inflammation Research. 4. Comas-Basté, O., Sánchez-Pérez, S., Veciana-Nogués, M.T., Latorre-Moratalla, M., Vidal-Carou, M.C. (2019); Histamine intolerance: the current state of the art; Biomolecules. Please Note: The impact of certain elements of pepperoni pizza on histamine levels needs further review. "This product has not been researched well enough to publish any information. Our team is working hard on this. Data will be available soon."