Orange Bitters Histamine Information

Oranges, and by extension, Orange Bitters, might potentially influence histamine levels. Citrus fruits like oranges are known to be histamine liberators, which means they may stimulate the release of histamine in the body, leading to an increase in histamine levels. While they don't carry histamine themselves, the interaction with the body's cells can trigger the release of stored histamine. However, the impact can vary significantly depending on individual sensitivities and tolerance levels (1). Orange Bitters is typically made from the peel of oranges, bitter herbs, and botanicals. Some of the ingredients apart from oranges can include gentian root and cinchona bark. Gentian root has not been sufficiently studied to establish its direct relationship with histamine levels. However, cinchona bark contains quinine, which can have potential interactions with histamines. Quinine is known to inhibit diamine oxidase (DAO), an enzyme responsible for breaking down histamines (2). This means that Orange Bitters might have a dual role on histamine. The orange peels aspect could stimulate histamine release, and the cinchona bark inclusion could inhibit histamine breakdown. Both mechanisms could potentially raise histamine levels. However, due to differing recipes for Orange Bitters and individual responses to these ingredients, the overall effect on histamine levels may vary widely. Seeing that the relationship between Orange Bitters and histamine isn't straightforward and is influenced significantly by it's various ingredients, the histamine effect can likely be best understood by the more extended study of its individual components. The concrete impact of Orange Bitters on histamine levels would require more targeted research. This product has not been researched well enough to publish any concrete information. Our team is working hard on this. Data will be available soon. References: (1) Wantke F., Gotz M., and Jarisch R. "Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches." Clinical & Experimental Allergy, December 1993, https://pubmed.ncbi.nlm.nih.gov/8298757/ (2) American Journal of Clinical Pathology, Oct 1985, https://academic.oup.com/ajcp/article-abstract/84/4/482/1761011?redirectedFrom=fulltext