Sambuca Liqueur Histamine Information

Sambuca, a popular Italian anise-flavored liqueur, is primarily composed of essential oils obtained from anise, star anise, licorice, and other spices, in addition to sugar and pure alcohol. However, specific studies exploring the impact of Sambuca on histamine levels are not readily available. We, therefore, examine the possible impacts based on its key ingredients. Anise, one of the dominant ingredients in Sambuca, contains substances that may exhibit anti-histaminic effects. A study suggests that anise oil has mast cell-stabilizing and anti-allergic activity, implying it may help reduce histamine release (1). On the other hand, alcohol in general, including liqueurs like Sambuca, has the potential to negatively impact histamine levels. Where studies suggest that moderate-to-high consumption of alcohol can cause an accumulation of histamine and may hinder its breakdown in the body, which might exacerbate histamine intolerance symptoms (2). Furthermore, alcohol can be a histamine liberator, prompting the release of this substance from other cells in the body (3). In conclusion, it is critical to consider these known interactions despite the specific impact of Sambuca on histamine levels remains somewhat uncertain due to the lack of related research. It is always recommended for individuals with histamine intolerance to exercise caution when consuming alcohol. References: 1. Shah, A. H., et al. (1991). Mast cell stabilizing and antiallergic activity of eugenol in addition to its known pharmacological activities–PubMed. Retrieved from https://pubmed.ncbi.nlm.nih.gov/1813490/ 2. Wantke, F., et al. (1993). Histamine in wine. bronchoconstriction after a double-blind placebo-controlled red wine provocation test–PubMed. Retrieved from https://pubmed.ncbi.nlm.nih.gov/8343652/ 3. Maintz, L., et al. (2007). Histamine and histamine intolerance–PubMed. Retrieved from https://pubmed.ncbi.nlm.nih.gov/17490952/