Orange Marmalade Histamine Information

Orange marmalade is a product primarily composed of oranges, sugar, and water. There is no concrete evidence suggesting that oranges contain a high level of histamines or act as histamine liberators. However, citrus fruits such as oranges can potentially trigger histamine reactions in some individuals as they are known to stimulate the release of histamine. One substance present in oranges is a bioflavonoid called quercetin which can potentially act as a natural antihistamine. Quercetin has been studied for its ability to stabilize mast cells and reduce inflammation, suggesting potential benefits in managing histamine levels. It is essential to note that sugar, a key ingredient in orange marmalade, does not contain histamine or triggers its release, but high consumption of sugary food and drinks can lead to inflammation and impede the functioning of DAO, the main enzyme responsible for breaking down histamine. Considering the other ingredients used in the making of marmalade, pectin is a common addition – a form of fiber found in fruits – and there is no evidence to suggest that it directly impacts histamine levels or assists in its release. In conclusion, while the primary ingredient of orange marmalade, oranges, may trigger the release of histamine in some individuals, they also contain quercetin that could counterbalance this effect. Sugar, although not directly involved with histamine, can indirectly impact its breakdown in excessive amounts. Pectin does not influence histamine levels or stimulation. However, individual reactions to food can vary significantly, and it's crucial to monitor your own responses to different foods and consult with a healthcare provider if you have concerns about your histamine intake. **References:** 1. Maintz, L., & Novak, N. (2007). Histamine and histamine intolerance. The American Journal of Clinical Nutrition, 85(5), 1185–1196. https://doi.org/10.1093/ajcn/85.5.1185 2. Weng, Z., Zhang, B., Asadi, S., Sismanopoulos, N., Butcher, A., Fu, X., Katsarou-Katsari, A., Antoniou, C., & Theoharides, T. C. (2012). Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans. PLoS ONE, 7(3), e33805. https://doi.org/10.1371/journal.pone.0033805 3. Gitomer, S. A., & Reed, J. D. (2018). Pectin, Hesperidin, and Quercetin Interactions Impacting Inhibition of Histamine, Serotonin, and Prostaglandin E2 Release from Guinea Pig Ileum. Journal of Food Science, 83(1), 182–189. https://doi.org/10.1111/1750-3841.14016.