Sage Leaves Histamine Information

Sage leaves, widely used in cooking and traditional medicine, contain numerous beneficial phytochemicals. Regarding their impact on histamine levels, scientific research is somewhat limited. However, studies have suggested that sage possesses anti-inflammatory and antioxidant properties, which could theoretically contribute to histamine regulation. Some research conducted on Salvia species, to which sage belongs, indicated possible antihistamine properties. However, these findings primarily pertain to sage essential oil rather than the whole leaves consumed as a part of diet (Kazemipoor, Radzi, Cordell, & Yaze, 2014). While Sage does not feature on most lists of high-histamine or histamine-liberating foods like the ones you've mentioned, it contains compounds like rosmarinic acid which has been shown in some studies to inhibit the release of histamines, specifically in allergic reactions (Osakabe, et al., 2004). For this reason, sage could potentially help to lower histamine levels, rather than increase them. Moving onto histamine-regulating foods, none of the ingredients associated with sage leaves are recognized for significantly raising histamine levels, functioning as histamine liberators, or notably delaying histamine breakdown. Please note that individual tolerance may vary, and dietary impact might depend on the total dietary context and not only the consumption of sage leaves in isolation. In summary, while existing research indicates sage might have a potential role in histamine regulation primarily due to its anti-inflammatory properties and compounds like rosmarinic acid, this herb does not appear to directly contribute to the increase in histamine levels or promote its release. More extensive research is needed to fully understand the impact of sage on histamine levels. References: - Kazemipoor, M., Radzi, C. W., Cordell, G. A., & Yaze, I. (2014). Potential of traditional medicinal plants for treating obesity: a review. International Journal of Comprehensive Pharmacy. - Osakabe, N., Takano, H., Sanbongi, C., Yasuda, A., Yanagisawa, R., Inoue, K. & Yoshikawa, T. (2004). Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism. Biofactors, 21(1-4), 127-131.