Lime Leaves Histamine Information

Lime leaves, commonly used in various culinary dishes, have not been extensively studied in relation to histamine levels in the human body, and comprehensive data on the subject is scarce. It should be noted, however, that the primary constituents of lime leaves are essential oils, flavonoids, and phenolic compounds, which have been associated with various health benefits. Some flavonoids found in lime leaves, like quercetin, are known for their potential antihistamine properties. Quercetin is known to inhibit the release of histamines in the body, thereby potentially reducing allergic reactions and inflammation (1). However, it is difficult to establish without substantial data whether the quantity of quercetin in lime leaves is sufficient to provide a significant antihistamine effect. Consequently, relying on lime leaves alone for histamine control may not be effective. Regarding the dietary factors influencing histamine levels, there is considerable research. Foods with a high histamine content such as red wine, hard cheese, and smoked or canned fish, can exacerbate histamine intolerance symptoms. In contrast, substances like pineapple and papaya that delay the degradation of histamine can potentially lead to increased histamine levels in the body (2). Certain products do not contain histamine but act as 'histamine liberators', triggering the release of histamine in the body. These include cocoa products, certain types of fruit like strawberries and citrus fruits, and some food additives. As such, people with histamine intolerance may need to be mindful of their consumption of these foods (3). In summary, while lime leaves contain flavonoids like quercetin which could potentially have antihistamine effects, robust clinical data to establish their impact on histamine levels is currently lacking. Bearing this in mind can be useful when assessing the dietary management of histamine intolerance. References: 1. Mlcek J, Jurikova T, Skrovankova S, Sochor J. Quercetin and Its Anti-Allergic Immune Response. Molecules. 2016 May;21(5):623. 2. Maintz L, Novak N. Histamine and histamine intolerance. American Journal of Clinical Nutrition. 2007 May;85(5):1185-96. 3. Schnedl WJ, Lackner S, Enko D, Schenk M, Holasek SJ, Mangge H. Evaluation of symptoms and symptom combinations in histamine intolerance. Intest Res. 2019 Oct;17(4):427-33.