Lettuce Histamine Information

Lettuce in general is low in histamine and is typically safe for individuals who have histamine intolerance. In fact, leafy green vegetables like lettuce are often suggested as part of a low histamine diet as they have very negligible amounts of this bioactive amine. However, the histamine levels can primarily be affected by freshness and storage conditions, as the degradation of amino acids could lead to the production of histamine in perishable foods after a certain time. What is crucial to understand is lettuce may theoretically act as a histamine liberator in some susceptible individuals. Though research on the exact mechanism is not robust, some sources suggest foods with considerable amine content can potentially trigger the body to release its own stored histamine. However, this has not been proven specifically for lettuce and thus should not be a deterrent for everyone to eliminate it from their diet. Moreover, no validated research suggests that lettuce can lower histamine levels. A low histamine diet primarily consists of fresh, unprocessed foods. Most fruits, vegetables (including lettuce), dairy substitutes, whole grains, fresh meat and fish, eggs, and selected oils, fats and vinegars are generally low in histamines and thus form a part of a low-histamine diet. To ascertain if lettuce causes any histamine related reactions, it would be best to seek registry dietitian or medical supervision for a reintroduction or challenge protocol as every individual's response to foods can be highly personalized. It's important to note these are general observations and the impact of lettuce on histamine levels could vary based on specific individual differences and the presence of other ingredients in meals. This product has not been researched well enough to publish any detailed information, our team is working hard on this. Data will be available soon. SOURCE: 1. Maintz L, Novak N. Histamine and histamine intolerance. The American journal of clinical nutrition. 2007 May 1;85(5):1185-96. 2. Histamine intolerance in detail. ImuPro. https://imupro.com.au/histamine-intolerance-in-detail/. Accessed September 15, 2021. 3. The Histamine Intolerance Food List to Follow for Symptom Control. Flo. https://flo.health/menstrual-cycle/health/syndrome-and-disorders/histamine-intolerance/histamine-intolerance-foods-list. Accessed September 15, 2021.