Macaroni and Cheese Histamine Information

Macaroni and Cheese, a popular comfort food, primarily comprises pasta and cheese. The histamine level impact of this meal essentially extends from its main constituents. Hard cheeses like cheddar, commonly used in Macaroni and Cheese, are long-ripened and hence notorious for relatively high histamine content [1]. However, this meal's histamine effect isn't entirely adverse; it also involves low histamine ingredients. Pasta, for instance, is generally ferment-free and not identified as having high histamine levels or eliciting its release [2]. Moreover, certain ingredients added to enhance the dish's flavor could lower histamine levels. For instance, onions and garlic, often used in the preparation, exhibit natural antihistamine properties [3]. Yet, the diversity of supplement ingredients like cheeses of varying aging periods, seasonings, and toppings, complicates the precise determination of the meal's histamine impact. For the individual, the cumulative effect would depend on the volumes consumed and how susceptible one is towards histamine [4]. Overall, Macaroni and Cheese might moderately affect your histamine levels, depending on your body's response, as it includes both potentially high histamine and low-impact ingredients. [1] Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007 [2] Schnedl WJ, Lackner S, Enko D, et al. Evaluation of symptoms and symptom combinations in histamine intolerance. Intest Res. 2019 [3] Kivimäki AS, Siltari A, Ehlers PI, Korpela R, Vapaatalo H. Histamine intolerance symptoms in healthy adults disappear with a histamine-free diet and recur with a histamine challenge in random order: a double-blind, placebo-controlled food challenge. Nutrients. 2020 [4] Viola G, Altomare A, Cecchi L, et al. A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria. Int Arch Allergy Immunol. 2019