Seitan Histamine Information

Seitan, frequently referred to as wheat meat, is a vegan meat alternative primarily composed of gluten, which is the protein component of wheat. It is made by washing wheat flour dough with water until all the starch granules have been removed, leaving the sticky insoluble gluten as an elastic dough which is then cooked before being eaten. The various ingredients used in making Seitan primarily consist of wheat gluten, water, and spices. None of these ingredients appear to contain high histamine levels or promote the release of histamine. Thus, Seitan might not significantly increase histamine levels. However, it should be considered that seasonings or spices, as well as certain cooking methods, could potentially alter this effect. For instance, if Seitan is prepared with tomatoes, vinegar, or smoked, it might influence the histamine levels due to the high histamine content or histamine-releasing properties in these substances. Gluten, a key ingredient in Seitan, has not been specifically tied to histamine release or any interaction with histamine levels in existing studies. Wheat, in general, does not appear on the lists of foods that are high in histamine, can induce histamine release, or that may inhibit DAO, the primary enzyme that metabolizes histamine, allowing for its clearance from the body. However, it is plausible for individual sensitivities to wheat or gluten to contribute to a histamine response, as inflammation and allergic reactions can lead to an increased histamine level in the body. It should be noted that this does not rule out the possibility of Seitan having an impact on histamine levels in some individuals, especially those with a histamine intolerance or allergy to wheat or gluten. Each individual may have a unique reaction depending on their unique biochemistry and the presence of any food sensitivities or allergic reactions. Thus, it is recommended that individuals with known histamine intolerance or other related conditions seek advice from a healthcare provider when considering including Seitan in their diet. The existing research on histamine content in Seitan or its ingredients seems to be deficient, therefore more concrete data is needed to fully understand the potential impacts of Seitan consumption on histamine levels. In conclusion, while the core ingredients of Seitan do not appear to possess high histamine content or significantly promote histamine release based on available information, the preparation method and potential individual sensitivities could influence the final impact on histamine levels. Ultimately, more research is imperative in this area. Please note, this information is subject to change as new research becomes available. (Source: Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007;85(5):1185-1196)