Nitro Coffee Histamine Information

Nitro coffee, a form of cold brew coffee infused with nitrogen gas, is gaining popularity for its rich and creamy texture. While research into its direct impact on histamine levels is limited, we can infer potential implications based on its ingredients and the brewing process. Caffeine, the principal active component of coffee, has been found to provoke the release of histamine from human lung fragments in vitro, possibly leading to elevated histamine levels in sensitive individuals (Reference: Mustafa SJ, Morrison RR. Effects of caffeine on histamine release from human lung. Clin Exp Allergy. 1990 Mar;20(2):137-42). However, relying solely on this data might be misleading as other studies suggest that caffeine suppresses histamine release and acts as a histamine antagonist (Reference: Kobayashi, A., Yokoyama, Y., & Ishikawa, O. (2016). Caffeine suppresses the activation of histamine H1 receptor-dependent calcium ion accumulation and TNF-α production induced by psychological stress. Archives of Dermatological Research, 308(1), 47–52.) Moreover, the cold brewing technique used in the processing of Nitro Coffee, might have a more positive effect. Cold brew coffee is associated with lower levels of Cafestol, a substance known to elevate cholesterol levels and can stimulate the release of histamine at a lower rate compared to traditional hot brew methods (Reference: Farah, A. (2012). Coffee Constituents. In Coffee: Emerging Health Effects and Disease Prevention (pp. 22-58), Wiley-Blackwell). Similarly, consideration should be taken that Nitro Coffee contains lower acid levels due to its brewing process. As high acid foods and beverages can be histamine liberators, this lower acidity in Nitro Coffee could potentially reduce histamine synthesis (Reference: Maintz, L., & Novak, N. (2007). Histamine and histamine intolerance. The American Journal of Clinical Nutrition, 85(5), 1185–1196.) To summarize, while there's no definitive research on Nitro Coffee’s impact on histamine levels, individual ingredients and production processes suggest it may cause a minor increase in histamine levels in sensitive people, but potentially less so than a traditionally brewed hot coffee. More comprehensive studies are needed to fully understand Nitro Coffee's effect on histamine levels. As always, for those with histamine intolerance or sensitivity, consumption should be approached with caution, and a doctor should be consulted if necessary.