Rosé Wine Histamine Information

Rosé wine, similar to other wines such as red and white, may indeed have considerable effects on the histamine level. In general, wines are known to contain histamine owing to the fermentation process they undergo, where histamine is produced by yeasts and bacteria especially during malolactic fermentation[^1^]. Although exact histamine content can vary between different types and vintages of wine, multiple studies have reported relatively lower histamine content in rosé wine compared to red wines[^2^]. Additionally, wine, including rosé wine, could potentially delay the breakdown of histamine, primarily due to the presence of alcohol[^3^]. This is because alcohol can interfere with the functioning of diamine oxidase (DAO), an enzyme that plays a key role in the metabolism and detoxification of histamine[^4^]. However, recent studies have highlighted a likely mitigating factor to this: a component found in wine known as quercetin. Quercetin, a form of flavonoid found in the skins of grapes used in winemaking, has been shown to have potential antihistaminic effects[^5^]. Quercetin can inhibit the release of histamine, therefore, the antihistamine function might balance or even overweigh the histamine-producing and releasing impact of the wine[^5^]. In conclusion, rosé wine could influence histamine levels due to its alcohol and potential histamine content, but also could potentially mitigate this impact due to the natural presence of quercetin. However, it is important to highlight that the histamine content or its impact can significantly vary depending on the precise winemaking process, and therefore, individual reactions can also vary. [^1^]: https://pubmed.ncbi.nlm.nih.gov/22082102/ [^2^]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393121/ [^3^]: https://pubmed.ncbi.nlm.nih.gov/8897596/ [^4^]: https://www.mdpi.com/2072-6643/5/9/3418/htm [^5^]: https://pubmed.ncbi.nlm.nih.gov/18384097/