Vitamin D Histamine Information

Vitamin D plays a key role in the body's immune response, including the management of histamine, a compound in the body involved in local immune responses. As reported by numerous studies, Vitamin D has substantial histamine-lowering impacts. It is beneficial for those with histamine intolerance, as vitamin D can counterbalance the abnormal histamine reaction in some individuals. A study by The Journal of Allergy and Clinical Immunology found that Vitamin D deficiency is often linked with higher histamine levels and more severe allergic reactions. Consuming a diet rich in Vitamin D can help manage histamine levels (source: Zhang Y, Leung DYM, Richers BN, et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Allergy Clin Immunol. 2012;129(3):755-763). While digressing into specific food items, Red wine, long-ripened cheese, smoked meats, mushrooms, and canned fish, all high in histamine, don't have any direct evidence indicating their contribution towards Vitamin D levels. Tomatoes, however, are a good source of Vitamin D. In contrast, foods delaying the histamine breakdown like pineapple, papaya, cocoa products, and nuts don't show a clear relation with changing Vitamin D levels. As for the histamine liberators, strawberries, citrus fruits, and invertebrate seafood have no conclusive research proving they affect Vitamin D levels. However, nutritional contents such as Vitamin C in strawberries can enhance Vitamin D absorption in the body. Further research and studies are required to explore and substantiate these relationships more authentically, especially for the foods that lack concrete research. The exception here being cocoa and nuts which are both histamine liberators and delay the breakdown of histamine but have not been researched well enough to publish any factual data on the impact these have on Vitamin D levels. This subject currently requires more research, and our team is working hard on this. Data will be available soon.