Vitamin A Histamine Information

Vitamin A is a critical nutrient involved in the functioning of various bodily systems. It is essential for maintaining vision, immune function, and promoting the normal growth and development of cells. Recent research indicates that vitamin A may influence histamine levels in the body and has potential impacts against histamine intolerance, but the exact mechanisms are still not entirely clear. High histamine food like red wine, and fermented food including aged cheese, yogurt, and pickled vegetables, all increase the histamine level in the body due to their long maturing processes. Tomatoes, a rich source of Vitamin A, appears on both the high histamine and histamine liberator food lists. However, there's insufficient scientific literature to detail the direct relationship between Vitamin A content in tomatoes and histamine levels (1). Cocoa products and energy drinks are sources of histamine and substances that delay the breakdown of histamine paired with being histamine liberators. Their impacts on histamine levels might be more associated with other constituents, such as biogenic amines, rather than their vitamin A content. Pineapple, rich in vitamin A, and papaya stand out in hindering histamine breakdown. However, their histamine activity is seemingly linked more to the presence of other active components, like enzymes bromelain in pineapple and papain in papaya (2). Similarly, the impact of alcohol on histamine relates to its histamine-releasing properties and its inhibitory effect on the enzyme diamine oxidase (DAO), responsible for histamine degradation (3). The red grapes used in producing French champagne have intrinsic histamine, possibly influencing the histamine content in wine. This product has not been researched well enough to publish any information, our team is working hard on this. Data will be available soon regarding the specifics of Vitamin A and its role in histamine regulation in the context of nuts, invertebrate seafood, yeast in baked goods, and certain additives, and preservatives. Research into the impacts and relationships of vitamin A on histamine levels is at its infancy, therefore more rigorous investigations are needed to establish concrete evidence. References: 1. https://pubmed.ncbi.nlm.nih.gov/15825129/ 2. https://www.researchgate.net/publication/8483726 3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705352/